HYDROXYMETHYL CYCLOHEXYLAMINES Russian patent published in 2014 - IPC C07C215/42 C07D333/20 C07C217/58 C07D471/04 C07D209/12 C07D209/14 C07C217/56 C07C217/54 C07C217/28 C07D491/52 A61K31/133 A61K31/135 A61K31/404 A61K31/407 A61K31/381 A61P29/00 A61P25/22 A61P25/24 A61P25/28 A61P25/30 A61P9/00 A61P9/10 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula (1), having affinity to the µ-opioid receptor and the to the ORL1 receptor, a medicinal agent containing said compounds and use thereof to obtain a medicinal agent for treating pain and other diseases. In general formula (1), Y₁, Y₁', Y₂, Y₂', Y₃, Y₃', Y₄ and Y₄' denote -H; R₁ and R₂ independently denote -CH₃; R₃ denotes R₀, where R₀ denotes C_1-8-alkyl; aryl, selected from phenyl which is unsubstituted or mono-substituted with -F, -Cl, -Br, -I, -CN or -OR₀, where R₀ denotes -C_1-3-alkyl; unsubstituted heteroaryl, selected from a 5-member heteroaryl with one S atom as a heteroatom; R₄ denotes R₀, where R₀ denotes aryl, selected from phenyl which is unsubstituted or mono-substituted with -F, -Cl, -Br, -I, -CN or -OR₀, where R₀ denotes -C_1-3-alkyl; 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indolyl, mono-substituted with -S(O)₂-phenyl; unsubstituted -dihydroisoindolyl or unsubstituted -indolyl; or R₄ denotes -OR₀ or -SR₀, where R₀ denotes a cycloaliphatic group selected from -C_5-6-cycloalkyl; aryl, selected from unsubstituted phenyl; C_1-2-alkylaryl, where aryl denotes phenyl, which is unsubstituted or mono-substituted with -OR₀, where R₀ denotes -C_1-3-alkyl; and R₅ denotes -H or -CH₃.

EFFECT: obtaining a medicinal agent for treating pain and other diseases.

7 cl, 3 tbl, 22 ex