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2 467 748

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IPC

A61K31/205(2006-01-01)

A61K31/195(2006-01-01)

A61P9/14(2006-01-01)

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Application

2011133234/15, 2011-08-08

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Start date

2011-08-08

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Actual filing date

2011-08-08

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Published

2012-11-27

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Inventor

Danilenko Ljudmila MikhajlovnaKharitonova Ol'Ga VladimirovnaSernov Lev NikolaevichSkachilova Sofija JakovlevnaKesarev Oleg GeorgievichSernova Aleksandra L'VovnaKesareva Zinaida AleksandrovnaPokrovskij Mikhail VladimirovichKhoshchenko Jurij AleksandrovichBratchikov Oleg IvanovichFiliminov Vjacheslav AleksandrovichNovikov Oleg OlegovichPokrovskaja Tat'Jana Grigor'EvnaZhiljakova Elena TeodorovnaKochkarov Vladimir IskhakovichNovikova Marina Jur'EvnaDegtjarenko Elena ViktorovnaFadeeva Dar'Ja AleksandrovnaKovalenko Boris StepanovichGolivets Tat'Jana Pavlovna

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

3-(2,2,2-TRIMETHYLHYDRAZINIUM) PROPIONATE DERIVATIVE - 3-(2,2,2-TRIMETHYLHYDRAZINIUM) POTASSIUM PROPIONATE GLYCINATE EXHIBITING ENDOTHELIOPROTECTIVE ACTIVITY Russian patent published in 2012 - IPC A61K31/205 A61K31/195 A61P9/14

Abstract RU 2467748 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is presented is the new chemical compound - a 3-(2,2,2-trimethylhydrazinium)propionate derivative - 3-(2,2,2-trimethylhydrazinium)potassium propionate glycinate, (CH3)3N⁺NHCH2CH2COOKRCOO^-, wherein exhibiting endothelioprotective activity. The presented derivative can find application in medicine in the integrated treatment for endothelial dysfunction correction in cardiovascular diseases.

EFFECT: enhanced endothelioprotective properties as compared with previously known mildronat due to the introduction of new functional group showing the most manifested antioxidant properties.

1 tbl

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RU 2 467 748 C1

Authors

Danilenko Ljudmila Mikhajlovna

Kharitonova Ol'Ga Vladimirovna

Sernov Lev Nikolaevich

Skachilova Sofija Jakovlevna

Kesarev Oleg Georgievich

Sernova Aleksandra L'Vovna

Kesareva Zinaida Aleksandrovna

Pokrovskij Mikhail Vladimirovich

Khoshchenko Jurij Aleksandrovich

Bratchikov Oleg Ivanovich

Filiminov Vjacheslav Aleksandrovich

Novikov Oleg Olegovich

Pokrovskaja Tat'Jana Grigor'Evna

Zhiljakova Elena Teodorovna

Kochkarov Vladimir Iskhakovich

Novikova Marina Jur'Evna

Degtjarenko Elena Viktorovna

Fadeeva Dar'Ja Aleksandrovna

Kovalenko Boris Stepanovich

Golivets Tat'Jana Pavlovna

Dates

2012-11-27—Published

2011-08-08—Filed