FIELD: medicine.
SUBSTANCE: invention concerns medicine, particularly to experimental cardiopharmacology and can be used for correction of endothelial dysfunction that is ensured by simulation thereof in experiment by daily intraperitoneal introduction to Wistar male rats within 7 days of N-nitro-L-arginine methyl ester in a dose 25 mg/kg. Degree of dysfunction development is estimated by relation of endothelium-independent to endothelium-dependent vasodilation. Correction of dysfunction is carried out by intragastric introduction of Tadalafil in a dose 0.9 mg/kg once a day.
EFFECT: method provides effective correction of endothelial dysfunction in specific simulation environment.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY COMBINATION OF TRIMETAZIDINE AND L-ARGININE IN L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY | 2009 |
|
RU2421822C2 |
| METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION BY PHOSPHOGLIV PREPARATION AT L-NAME INDUCED DEFICIENCY OF NITROGEN OXIDE | 2008 |
|
RU2359668C1 |
| METHOD OF ACETYLSALICYLIC ACID BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364392C1 |
| METHOD OF CLOPIDOGREL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364394C1 |
| METHOD OF LAMOTRIGINE CORRECTION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
RU2367421C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH SOLVENT MIXTURE OF HOMEOPATHIC DILUTIONS OF POLYCLONAL RABBIT ANTIBODIES TO HUMAN ENDOTHELIAL NITROGEN OXIDE SYNTHASE C12, C30, C200 | 2006 |
|
RU2306953C1 |
| METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
RU2364393C1 |
| METHOD FOR COMBINED TADALAFIL AND L-NORVALINE CORRECTION OF L-NAME INDUCED NITROGEN OXIDE DEFICIENCY IN EXPERIMENT | 2012 |
|
RU2500040C1 |
| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY | 2005 |
|
RU2306924C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF ENALAPRIL AND RESVERATROL IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE | 2005 |
|
RU2301670C1 |
