FIELD: medicine, experimental cardiopharmacology.
SUBSTANCE: it is necessary to model endothelial dysfunction due to daily intraperitoneal injection of L-nitro-arginine-methyl ether (L-NAME) for rats during 7 d at the dosage of 25 mg/kg. At the background of modeling the dysfunction one should perform its correction due to simultaneous injection of indapamide intragastrally at the dosage of 2 mg/kg and resveratrol intraperitoneally at the dosage of 2 mg/kg once daily. The innovation provides efficient correction of endothelial dysfunction induced by inhibiting NO synthase due to combined injection of indapamide and resveratrol.
EFFECT: higher efficiency of correction.
1 ex, 2 tbl
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