FIELD: medicine.
SUBSTANCE: claimed is bacterium-producent of diaminomonocarboxylic L-amino acid, selected from L-lysine, L-arginine, L-ornithine and L-citrulline, belonging to Enterobacteriaceae family, modified in such a way that in said bacterium weakened is expression of one or several genes, coding lysine/arginine/ornithine transporter and one or several genes, coding histidine transporter, represented by cluster argT-hisJQMP. Claimed is method of obtaining diaminomonocarboxylic L-amino acid, which includes: growing of said bacterium in nutritional medium, inducing production and secretion of said L-amino acid into culture liquid and isolation of said L-amino acid from culture liquid.
EFFECT: invention makes it possible to obtain said diaminomonocarboxylic L-amino acid in larger volume.
9 cl, 2 tbl, 5 ex
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Authors
Dates
2012-11-27—Published
2011-04-25—Filed