METHOD OF PRODUCING 7-[2-(2-AMINOTHIAZOL-4-YL)-2(Z)-METHOXYIMINO ACETAMIDO]-3-[(1-METHYL-1-PYRROLIDINO)METHYL]-CEF-3-EM-4-CARBOXYLATE DIHYDROCHLORIDE MONOHYDRATE (CEFEPIME DIHYDROCHLORIDE MONOHYDRATE) Russian patent published in 2012 - IPC C07D501/12 C07D501/46

Abstract RU 2469040 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 7-[2-(2-aminothiazol-4-yl)-2(Z)-methoxyimino acetamido]-3-[(1-methyl-1-pyrrolidino)methyl]-cef-3-em-4-carboxylate dihydrochloride monohydrate (cefepime dihydrochloride monohydrate) of formula (I) The method is realised by crystallising 7-[2-(2-aminothiazol-4-yl)-2(z)-methoxyimino acetamido]-3-[(1-methyl-1-pyrrolidino)methyl]-cef-3-em-4-carboxylate dihydrochloride monohydrate from aqueous or aqueous-organic solutions thereof by adding sodium chloride to the solution in an amount which provides sodium chloride concentration in the formed solution ranging from 10.0 to 15.0%. The precipitated cefepime dihydrochloride is then filtered, washed and dried.

EFFECT: improved method of producing cefepime dihydrochloride monohydrate.

2 cl, 2 ex

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RU 2 469 040 C1

Authors

Greben'Kov Vladimir Ivanovich

Savel'Ev Evgenij Aleksandrovich

Dates

2012-12-10—Published

2011-12-07—Filed