FIELD: medicine.
SUBSTANCE: for the purpose of prediction of the effectiveness of neoadjuvant chemotherapy in breast cancer patients, the radical surgery involves sampling a piece of malignant tissue 100-150 mg. Then 10% homogenate is prepared and analysed for the content of estrogen-2 metabolites - hydroxyestrone 2-OHE1 and 16α-hydroxyestrone 16α-OHE1. The relation 2OHE/116α-OHE1 is calculated, and the value being more than 1.5 enables predicting the onset of clinical effect of the conducted neoadjuvant therapy.
EFFECT: method enables predicting the clinical effectiveness of the neoadjuvant therapy in breast cancer patients.
2 ex, 1 tbl
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