FIELD: medicine, pharmaceutics.
SUBSTANCE: what is presented is the use of N-vinylpyrrolidone copolymer presented by general formula 
(I) wherein a monomer link M represents a fragment of 2-methyl-5-vinyltetrazole 
(MVT) or 2-methyl-5-vinylpyridine 
(MVP) and the monomer link content n makes 25-90 mole %, while a viscosity-average molecular weight Mµ of the copolymer depends of the M nature: if M represents MVT, then Mµ=100-250 kDa; if M represents MVT, then Mµ=46-150 kDa in a dose of 200 to 2000 mcg/kg (previously known as a phagocytosis activator) as an agent potentiating an analgesic effect of morphine hydrochloride. A reliable increase of a pain threshold combined with the simultaneous introduction of the copolymer and morphine hydrochloride is shown.
EFFECT: invention provides a double reduction of the morphine dose with keeping a level of analgesia.
4 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COPOLYMERS OF 2-METHYL-5-VINYL-PYRIDINE AND N-VINYL PYRROLIDONE, HAVING PHAGOCYTOSIS ACTIVATOR PROPERTIES | 2010 |
|
RU2430933C1 |
| COPOLYMERS OF 2-METHYL-5-VINYL-PYRIDINE AND N-VINYLPYRROLIDONE, ACTIVATING PRODUCTION OF INTERLEUKIN-1, AND USE THEREOF AS ANTI-CANCER AGENTS | 2010 |
|
RU2430932C1 |
| COPOLYMER CONTAINING N-VINYL PYRROLIDONE, 2-METHYL-5-VINYL PYRIDINE AND 4-VINYL PYRIDINE LINKS | 2011 |
|
RU2459838C1 |
| N-VINYLPYRROLIDONE BASED COPOLYMERS | 2010 |
|
RU2415876C1 |
| N-VINYLPYRROLIDONE-BASED COPOLYMERS IN FORM OF PHARMACEUTICALLY ACCEPTABLE SALTS OF ACIDS | 2013 |
|
RU2533113C1 |
| OPHTHALMIC PREPARATION PRESENTED IN FORM OF EYE DROPS AND CONTAINING BRANCHED POLYHEXAMETHYLENE GUANIDINES | 2012 |
|
RU2510264C1 |
| SOLID DOSAGE FORM OF TAURINE WITH IMPROVED PHARMACOLOGICAL PROPERTIES | 2012 |
|
RU2495663C1 |
| OPHTHALMIC PREPARATION PRESENTED IN FORM OF EYE DROPS AND CONTAINING BRANCHED POLYHEXAMETHYLENE GUANIDINES AND POLY(N-VINYLPYRROLIDONE) | 2012 |
|
RU2509562C1 |
| COPOLYMERS OF 4-VINYLPYRIDINE OR 2-METHYL-5-VINYLPYRIDINE AND N-VINYLPYRROLIDONE WITH TERMINAL CYANOVALERIC ACID RESIDUE AND USE THEREOF TO TREAT PNEUMOCONIOSIS | 2014 |
|
RU2550820C1 |
| INTERPOLYMER POLYELECTROLYTE COMPLEX AND A PROLONGED IMMUNOSTIMULATING AGENT ON ITS BASIS, FOR MEDICAL AND VETERINARY USE | 2017 |
|
RU2683947C1 |
