AMIDES OF 2-(2-HYDROXYPHENYLTHIO)ACETIC ACID, HAVING ANTIOXIDANT ACTIVITY, AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2013 - IPC C07C323/18 A61K31/95 A61P39/06 

FIELD: chemistry.

SUBSTANCE: invention relates to amides of 2-(2-hydroxyphenylthio)acetic acid, having antioxidant activity, which are phenol derivatives having in the ortho-position a thioacetamide fragment of general formula: , where R¹=H, Me; R²=H, CH₂COOMe, CH(Me)COOMe, CH(Et)COOMe, CH(i- Pr)COOMe, CH(i-Bu)COOMe, CH(Bn)COOMe, CH(4-HOBn)COOMe, CH(CH₂CH₂SMe)COOMe, CH₂COOH, CH(Me)COOH, CH(Et)COOH, CH(i- Pr)COOH, CH(i-Bu)COOH, CH(Bn)COOH, CH(4-HOBn)COOH, CH(CH₂CH₂SMe)COOH, CH₂CH₂CH₂CH₂CH(MH₂)COOH, CH₂CH₂CH₂CH(NH₂)COOH; R³=H; R²R³=CH₂CH₂N(C(O)CH₂S(2-OHPh))CH₂CH₂; R²,R³=CH₂CH₂CH₂CH(COOMe); R²,R³=CH₂CH₂CH₂CH(COOH). The invention also relates to a method of producing the said compounds.

EFFECT: compounds have antioxidant activity, which enables use thereof to reduce the rate of peroxide oxidation of lipids.

2 cl, 3 tbl, 8 ex