SUBSTITUTED DERIVATIVES OF N-BENZYLINDOL-3-YL-GLYOXYLIC ACID POSSESSING ANTITUMOR EFFECT (VARIANTS), THEIR ACID-ADDITIVE SALTS (VARIANTS), PHARMACEUTICAL PREPARATION, PHARMACEUTICAL FORMULATION Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to substituted derivatives of N-benzylindol-3-yl-glyoxylic acid of the formula (1): wherein groups R, R₁, R₂, R₃, R₄ and Z have the following values: R means -NO₂, -NH₂, (C₁-C₆)-acylamino-, aroylamino-, nicotinoyl or isonicotinoyl, arylsulfonylamino-, succinimido- wherein this residue R can be substituted with (C₁-C₆)-group by choosing by carbon atom at positions 2, 3 and 4 of phenyl ring; R₁ means hydrogen atom (H), (C₁-C₆)-alkyl that can be replaced with at least one phenyl group; R₂ means pyridyl; R₃ and R₄ mean H; Z means oxygen (O), sulfur (S) atom. Compounds of the formula (1) possess an antitumor effect that allows their using in pharmaceutical compositions.

EFFECT: valuable medicinal properties of compounds and compositions.

6 cl, 2 dwg, 3 tbl, 9 ex