RECOVERED MYELOID-LIKE CELL POPULATIONS AND METHOD OF TREATING WITH USING SUCH POPULATIONS Russian patent published in 2013 - IPC C12N5/71 C12N5/10 A61K48/00 A61P27/02 

Abstract RU 2473686 C2

FIELD: medicine.

SUBSTANCE: cell population is recovered from peripheral blood or umbilical blood by a method involving positive cell secretion from peripheral blood or umbilical blood able for immune reaction with an antibody specified in a group consisting of aHTH-CD44, anti-CD11b and their combination. The recovered myeloid-like cell population contains the cells expressing CD44 antigen, CD11b antigen and hypoxia-induced factor lα (HIF-lα). The prepared population is used for recovery and stabilisation of the functional vasculature, stimulation of microgliacyte formation, and for stimulation of physiologic intra-retinal vascularisation of hypoxic retinal tissue in simultaneous suppression of abnormal preretinal vessel formation.

EFFECT: invention enables preparing the cells with vasculotrophic and neurotrophic activity which possess a considerable therapeutic potential in the intraocular introduction into a mammal suffering a degenerative ocular disease.

7 cl, 63 dwg, 2 tbl, 21 ex

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RU 2 473 686 C2

Authors

Fridlehnder Martin

Ritter Mehtt'Ju R.

Moreno Stejsi K.

Marketti Valentina

Dates

2013-01-27Published

2007-11-16Filed