ISOLATED POPULATIONS OF MYELOID-LIKE CELLS OF BONE MARROW AND METHODS OF TREATMENT WITH THEM Russian patent published in 2011 - IPC C12N5/77

Abstract RU 2418856 C2

FIELD: medicine.

SUBSTANCE: method of isolating myeloid-like cells of bone marrow is realised by processing bone marrow cells with antibodies against CD44 ( hyaluronic acid receptor), against CD11b or against both, and with application of flow cytometry. After that, positive selection from them of cells, expressing CD44 and/or CD11b, is carried out. Isolated myeloid-like cells of bone marrow can be transformed with the gene, coding therapeutically applicable protein, to deliver the gene into the retina.

EFFECT: obtained cells possess favourable vasculotrophic and neurotrophic activity, when introduced intraocularly into and eye of a mammal.

21 cl, 46 dwg, 3 tbl, 17 ex

Similar patents RU2418856C2

Title	Year	Author	Number
METHOD OF TREATING RETINOPATHY IN PREMATURITY AND RELATED RETINOPATHIC DISEASES	2006	Fridlehnder Martin Banin Ehjjal Agilar Ehdit	RU2403906C2
RECOVERED MYELOID-LIKE CELL POPULATIONS AND METHOD OF TREATING WITH USING SUCH POPULATIONS	2007	Fridlehnder Martin Ritter Mehtt'Ju R. Moreno Stejsi K. Marketti Valentina	RU2473686C2
HAEMATOPOIETIC STEM CELLS AND METHODS OF TREATING NEOVASCULAR OPHTHALMOPATHIES WITH USING THEREOF	2006	Fridlehnder Martin Otani Atsusi Dasilva Karen Khejnekehmp Stejsi	RU2389497C2
HEMATOPOETIC STEM CELLS AND METHODS OF TREATMENT OF NEOVASCULAR EYE DISEASES USING THEREOF	2004	Fridlehnder Martin Otani Atsusi Dasilva Karen Khejnekehmp Stejsi	RU2345780C2
HEMOPOIETIC STEM CELLS POPULATION AND ITS APPLYING	2003	Fridlehnder Martin Otani Atsusi Dasilva Karen	RU2331669C2
SELECTIVE R-CADHERIN ANTAGONISTS AND METHODS	2004	Fridlehnder Martin Dorrell Majkl I.	RU2349598C2
REVASCULARISATION OF ISCHEMIC RETINAL TISSUE AND SCREENING TECHNIQUE	2006	Fridlehnder Martin Banin Ehjjal Agilar Ehdit	RU2401124C2
POLYPEPTIDES DERIVED FROM TRYPTOPHANYL-TRNA-SYNTHETASE AND USES THEREOF IN CONTROLLING OF VASCULARISATION	2002	Shimmel' Pol Vakasugi Kejsuke Frehdlehnder Martin	RU2297425C2
REPROGRAMMING HUMAN ENDOTHELIUM IN HEMATOPOIETIC PRECURSORS OF MULTIPLE LINES OF DIFFERENTIATION USING CERTAIN FACTORS	2014	Sandler Vladislav M. Rafii Shakhin	RU2691062C2
METHOD OF HEAMATOPOIETIC STEM CELL GROWTH MODULATION	2007	Zon Leonard I. Nort Trista Eh. Gessling Vol'Fram	RU2425876C2

RU 2 418 856 C2

Authors

Fridlehnder Martin

Ritter Mehtt'Ju R.

Moreno Stejsi K.

Dates

2011-05-20—Published

2006-02-24—Filed