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2 473 700

(13)

(51)

IPC

C12Q1/68(2006-01-01)

(21) (22)

Application

2011104564/10, 2011-02-09

(24)

Start date

2011-02-09

(22)

Actual filing date

2011-02-09

(45)

Published

2013-01-27

(72)

Inventor

Anisimenko Maksim SergeevichKovalenko Sergej Petrovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Molekuljarnoj Biologii I Biofiziki Sibirskogo Otdelenija Rossijskoj Akademii Meditsinskikh Nauk So Ramn)Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Nauchnyj Tsentr Institut Organicheskikh Poluproduktov I Krasitelej"Obshchestvo S Ogranichennoj Otvetstvennost'Ju

METHOD FOR DETECTION OF BRCA1 5382insC AND CHEK2 1100delC MUTATIONS Russian patent published in 2013 - IPC C12Q1/68

Abstract RU 2473700 C2

FIELD: medicine.

SUBSTANCE: invention may be used for determining mutation frequency in a population when analysing DNA wide samples. A method involves determining the DNA concentration in the analysed samples. A maximum possible number of samples in one pull is evaluated. The samples are mixed in the pull to be analysed for the presence of mutations in the pull by allele-specific real-time polymerase chain reaction. The pulls containing the mutation are additionally analysed by determining the range of the DNA sample concentrations within a reliable sample from all the analysed samples. After the maximum possible number of samples in one pull is determined, the pull is made of individual samples with different concentrations.

EFFECT: invention enables considerably reduced cost and length of the analysis of DNA wide samples for the presence of mutations.

3 dwg, 2 ex

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RU 2 473 700 C2

Authors

Anisimenko Maksim Sergeevich

Kovalenko Sergej Petrovich

Dates

2013-01-27—Published

2011-02-09—Filed