FIELD: medicine.
SUBSTANCE: what is presented is a method for stating a higher risk of breast cancer in a human individual based on the analysis results of a DNA sample for the presence of SNP in positions 142, 355 and 4326 of CYP1B1 gene; deletion versions 1100 delC, del5395, as well as 1VS2+1G>A CHEK2 gene and substitution of C5972T in BRCA2 gene. It is combined with combined genotypes in all said position of the three genes wherein a risk of developing breast cancer exceeds total effects determined by the related versions of each of the three genes separately which are considered to be a sign of particular breast cancer susceptibility (disproportionally high risk of the disease) of the individual. This method is high probability applicable for analysis of various ethnic groups.
EFFECT: improved diagnostic accuracy.
10 cl, 2 tbl, 1 ex
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