FIELD: medicine.
SUBSTANCE: invention refers to medicine, molecular biology and biotechnology. What is presented is a method for determining the polymorphism of human GP6 gene coding glycoprotein VI by the polymorphous position rs 1613662 based on recording melting curves with fluorescence-labelled allele-specific oligonucleotide tests.
EFFECT: due to the more reliable determination of variable positions and a possibility to detect in one test tube with the use of standard equipment, the method can be effectively used to diagnose the individual's inherited predisposition with the recording the real-time PCR results.
1 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DETERMINING HUMAN GENOTYPE BY POLYMORPHISM IN MATRIX METALLOPROTEINASE MMP9-1562 C>T (rs3918242) GENE | 2012 |
|
RU2548811C2 |
| METHOD OF DETERMINING HUMAN GENOTYPE ON POLYMORPHISM IN TYPE II COLLAGEN GENE COL2A1 C>A (RS1635529) | 2012 |
|
RU2518301C1 |
| METHOD FOR DETERMINING MUTATION IN HUMAN GALACTOSE-1-PHOSPHATURIDYL TRANSFERASE GENES Q188R, RS75391579 | 2017 |
|
RU2675324C1 |
| METHOD FOR HUMAN GENOTYPE DETERMINATION BY POLYMORPHISM IN MATRIX METALLOPROTEINASE 3 (MMR3) -11715A/6A GENE | 2018 |
|
RU2699053C1 |
| METHOD FOR DETERMINING HUMAN GENOTYPE BY POLYMORPHISM IN THE CYTOCHROME GENE P450 CYP2D6∗3 (2549DELA), RS35742686 | 2016 |
|
RU2651770C2 |
| METHOD FOR DETERMINING THE HUMAN GENOTYPE BY POLYMORPHISM IN THE CYTOCHROME P450 CYP2D6*6 (1707DELT) RS5030655 GENE | 2016 |
|
RU2653492C2 |
| METHOD FOR DETERMINING HUMAN GENOTYPE BY POLYMORPHISM IN THE CYTOCHROME GENE P450 CYP2D6*9 (2615-2617DELAAG) RS5030656 | 2016 |
|
RU2651773C2 |
| METHOD FOR DETERMINING THE HUMAN GENOTYPE BY POLYMORPHISM IN THE CYTOCHROME P450 GENE CYP2D6*4 (1846G>A), RS3892097 | 2016 |
|
RU2651774C2 |
| DIAGNOSTIC TECHNIQUE FOR THE 167DELT (RS80338942) MUTATION OF THE GJB2 GENE | 2020 |
|
RU2739943C1 |
| DIAGNOSTIC TECHNIQUE OF 35DELG (RS80338939) MUTATION OF GJB2 GENE | 2020 |
|
RU2739889C1 |
