FIELD: medicine.
SUBSTANCE: invention describes a method for detection of steroid resistance in the patients with true acantholytic pemphigus based on the analysis of the changes of secondary messengers wherein peripheral lymphocytes are sampled from the patient suffering true acantholytic pemphigus, processed in concanavalin A, analysed for the level of lymphocyte inositol trisphosphate by ion-exchange chromatography on organic resin before prescribing the therapy with systemic glucocorticoids and after prescribing the therapy with systemic glucocorticoids; if observing the intracellular level of lymphocyte inositol trisphosphate in the presence of systemic glucocorticoids by 10-15%, a form of the patient's disease is considered to be steroid-sensitive, while no changes of the level show a steroid-resistant form of the disease.
EFFECT: method enables detecting the patients with true acantholytic pemphigus resistant to the therapy with systemic glucocorticoids for ensuring faster remission of the disease and selection of the adequate therapy, reducing therapeutic doses of systemic glucocorticoids to the maintaining ones with no recurrences of the disease.
2 ex, 2 dwg
Title | Year | Author | Number |
---|---|---|---|
METHOD OF TREATING PEMPHIGUS VULGARIS | 2012 |
|
RU2530625C2 |
ACANTHOLYTIC PEMPHIGUS TREATMENT METHOD | 2009 |
|
RU2391984C1 |
METHODS FOR USING PROGESTOGEN AS GLUCOCORTICOID SENSITISER | 2011 |
|
RU2575824C2 |
METHOD OF TREATMENT OF PATIENTS WITH BACKBONE AND SPINAL CORD DAMAGE | 2000 |
|
RU2171677C1 |
GREEN TEA-BASED COMPOSITION CONTAINING ADDITIVES OF ASCORBIC ACID, DIHYDROMELETIN, SODIUM SELENITE, POTASSIUM IODIDE AND ZINK SULFATE, ITS PRODUCTION AND USAGE METHOD | 2007 |
|
RU2370047C2 |
METHOD OF TREATING CHRONIC RECURRING INFLAMMATORY DISEASES OF NASAL CAVITY AND PARANASAL SINISES BY METHOD OF ENDONASAL AUTOLYMPHOCYTO THERAPY | 2009 |
|
RU2403071C1 |
METHOD FOR IMMUNOTHERAPY OF CHRONIC REFRACTORY HERPES VIRUS INFECTION | 2011 |
|
RU2485962C1 |
COMBINATION OF METHYLXANTHINE COMPOUNDS AND STEROIDS FOR TREATMENT OF CHRONIC RESPIRATORY DISEASES | 2006 |
|
RU2395285C2 |
COMBINATION AND PHARMACEUTICAL PREPARATION FOR TREATMENT OF INFLAMMATORY DISEASES | 2006 |
|
RU2465915C2 |
METHOD FOR TREATING ONCOLOGICAL DISEASES | 2018 |
|
RU2675233C1 |
Authors
Dates
2013-01-27—Published
2011-05-16—Filed