FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-micaminosyl-tylonolide having characteristics specified in the description. The application materials also present methods for preparing such crystalline forms. The invention declares a pharmaceutical composition for treating hemorrhagic septicemia, ruminant respiratory disease and swine respiratory disease, containing 20,23-dipiperidinyl-5-O-micaminosyl-tylonolide in the solid form wherein a therapeutically effective amount of 20,23-dipiperidinyl-5-O-micaminosyl-tylonolide in the composition consists of a substantially pure phase of the crystalline form or at least 50% of 20,23-dipiperidinyl-5-O-micaminosyl-tylonolide in the composition consists of a crystalline form.
EFFECT: use of the therapeutically effective amount of the pharmaceutical composition for preparing the drug for treating hemorrhagic septicemia, ruminant respiratory disease and swine respiratory disease.
13 cl, 23 ex, 22 tbl, 40 dwg
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