FIELD: chemistry.
SUBSTANCE: invention presents several polymorphous forms and an amorphous form of {2-fluorine-5-[3-((E)-2-pyridine-2-ilvinyl)-1N-indazole-6-ilamine]phenyl}amide 2, 5-dimethyl-2N-pyrazole-3-carbonic acid, a pharmaceutical formula containing such polymorphous or amorphous forms, as well as ways of using such pharmaceutical formulas for therapy of ill conditions mediated by protein kinases such as cancer and other pathological conditions associated with undesirable angiogenesis and/or cell proliferation, as well as the mode of modulating protein kinase receptor activities on the basis of the polymorphous forms.
EFFECT: obtained polymorphous forms possess improved solubility and biological accessibility when taken per os.
22 cl, 40 dwg, 18 ex
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