FIELD: chemistry.
SUBSTANCE: invention relates to immunology. Disclosed is an immunostimulating oligonucleotide 5' TCGTCGTTTTTCGGTGCTTTT 3'. Described are versions of using the oligonucleotide to obtain an immunostimulating oligonucleotide with the same immunostimulating activity with at least one lipophilic substituted nucleotide analogue or as an adjuvant in a vaccine for inducing antigen-specific immune response.
EFFECT: use of the invention provides an immunostimulating oligonucleotide which causes, in a population of CD4+ T-cells, production of a large amount of T-cells which secrete IFN-gamma and more polyfunctional T-cells than ODN 5' TCGTCGTTTTTCGGTCGTTTT 3', which can be utilised in medicine.
25 cl, 21 dwg, 3 tbl, 4 ex
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