FIELD: chemistry.
SUBSTANCE: invention relates to field of biotechnology, in particular to immunogens based on antigenic tau-peptide, and can be used in medicine. Obtained is immunogen, which contains antigenic tau-peptide, consisting of amino acid sequence, selected from SEQ ID NO:6, 8-19, 21-26, 105 and 108-112, covalently bound with immunogenic carrier by means of linker, represented by formula (G)nC, where n equals 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10. Linker can be located either on C-terminal (peptide -(G)nC), or on N-terminal (C(G)n-peptide) of peptide. Obtained immunogens are used as base for creation of pharmaceutical compositions for treatment of tau-associated neurological disorders.
EFFECT: invention makes it possible to induce immune response against tau autoantigen in efficient way.
12 cl, 10 dwg, 5 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CH3 IGE PEPTIDE VACCINE | 2009 |
|
RU2495049C2 |
| PCSK9 VACCINE | 2010 |
|
RU2538162C2 |
| CONJUGATES OF PEPTIDE Melan-A, VIRUS-LIKE PARTICLE ANALOGUE | 2004 |
|
RU2351362C2 |
| CONJUGATE OF ANGIOTENSIN PEPTIDE COMPONENT WITH CARRIER, VACCINE COMPOSITION, METHOD OF ANIMAL IMMUNISATION AND METHOD OF TREATMENT OR PREVENTION OF PHYSICAL DISORDER RELATED TO ANGIOTENSIN SYSTEM ACTIVATED BY RENIN | 2002 |
|
RU2350622C2 |
| FMDV VACCINES BASED ON A RECOMBINANT ADENOVIRAL VECTOR AND USE THEREOF | 2017 |
|
RU2725495C2 |
| IMMUNOGENIC COMPOSITION, VACCINE COMPRISING SAME, KIT FOR PREPARING SAID COMPOSITION AND METHOD OF TREATING DISEASES ASSOCIATED WITH GASTRIN SECRETION PATHOLOGY | 2014 |
|
RU2664197C2 |
| METHODS AND COMPOSITION FOR INHIBITION OF HIV-1 MULTIPLICATION | 2001 |
|
RU2275379C2 |
| IMMUNOGENE COMPOSITION ON BASIS OF ANTIGEN Chlamydia trachomatis (VERSIONS) AND ITS USE | 2004 |
|
RU2352356C2 |
| VACCINES BASED ON VIRUS-LIKE PARTICLES (VLP) OF CANINE PARVOVIRUS (CPV) AND APPLICATION THEREOF | 2016 |
|
RU2710854C1 |
| COMPOSITIONS OF RECOMBINANT CDV AND ITS USE | 2011 |
|
RU2567337C2 |
