NUCLEOSIDE PHOSPHORAMIDATES AS ANTIVIRAL AGENTS Russian patent published in 2013 - IPC C07H19/10 C07H19/20 A61K31/7064 A61K31/7076 A61P31/14 

Abstract RU 2478104 C2

FIELD: medicine.

SUBSTANCE: invention refers to isopropyl ester of (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-ftor-3-hydroxy-4-methyl-tetrahydrofuran-2-ylmethoxy]-phenoxy-phosphorylamino}-propionic acid and its stereoisomer which may be used for treating viral infections in mammals, a method for preparing it, based compositions and the use thereof for treating viral diseases. The prepared method involves a reaction of the compounds

and ,

wherein X' represents a leaving group.

EFFECT: what is presented is the new effective agent for treating the diseases caused by hepatitis A and C, West Nile encephalitis, yellow fever, Aden fever, bovine diarrhoea, Japanese encephalitis viruses, rhinovirus, poliovirus, and an effective method for preparing it.

14 cl, 82 ex, 32 tbl

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RU 2 478 104 C2

Authors

Sofija Majkl Dzh.

Du Dzhinfa

Van Pejjujan'

Nagaratkhnam Dkhanapalan

Dates

2013-03-27Published

2008-03-26Filed