FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to spirocyclic nitriles of formula 
(1a): wherein the radicals A, B, C, X, Y, R24, R25, R26 and R27 are presented in cl.1 of the patent claim, inhibiting thiol proteases, particularly cathepsins, a method for preparing and using them as a drug for treating the diseases directly or indirectly mediated by cathepsins.
EFFECT: preparing the agent for treating the diseases directly or indirectly mediated by cathepsins.
12 cl, 2 tbl, 105 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | 2012 |
|
RU2621695C2 |
| PHARMACEUTICAL AGENT CONTAINING INHIBITOR OF SODIUM-DEPENDENT PHOSPHATE CARRIER | 2015 |
|
RU2740008C2 |
| NEW COMPOUNDS AND COMPOSITIONS FOR CATHEPSIN INHIBITION | 2004 |
|
RU2346943C2 |
| 2-AMINOBENZOTHIAZOLYLUREAS AS ADENOSINE MODULATORS | 2002 |
|
RU2311905C2 |
| PHARMACEUTICAL PRODUCT CONTAINING INHIBITOR OF SODIUM DEPENDENT PHOSPHATE CARRIER | 2015 |
|
RU2811864C1 |
| SPIROCOMPOUND OR SALTS THEREOF, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON HAVING ANTIMICROBIAL ACTIVITY | 1989 |
|
RU2094432C1 |
| NEW DIAMIDES PYRIMIDIN-4,6 OF DICARBOXYLIC ACID FOR SELECTIVE INHIBITION OF COLLAGENASES | 2003 |
|
RU2344129C2 |
| ANTAGONISTS OF VITRONECTIN RECEPTOR, THEIR PREPARING AND APPLICATION | 1997 |
|
RU2198892C2 |
| DERIVATIVES OF BENZIMIDAZOL INHIBITING FACTOR Xa | 2004 |
|
RU2346944C2 |
| DERIVATIVES OF AMINOINDAZOLS AND THEIR APPLICATION AS KINASES INHIBITORS | 2003 |
|
RU2339624C2 |
