FIELD: medicine. SUBSTANCE: product of formula 1 wherein a is 1, b is 2, c is 1-2; z is 
; R1 is amino group, hydroxy group, C1-C6 hydroxy alkyl; R2 is H, C1-C6 alkyl and Q is group of formula 2 in which R3 is C1-C6 alkyl substituted or unsubstituted by cycloalkyl group having 3 to 6 carbon atoms or 2,4-difluorophenyl group; A is nitrogen atom or group of formula 3 in which R is H, C1-C6 alkyl or halogen atom, R3+R4 is tricyclic ring of formula 4 in which X is halogen, Y is H or C1-C6 alkyl. Reagent 1: spirocyclic ring of formula 5. Reagent 2: compound of formula 6 or 7. Structural formulae of compounds 1,2,3,4,5,6 or 7 are as follows: 
. EFFECT: improved properties of the pharmaceutical composition. 9 cl, 1 tbl
