DISPIROPYRROLIDINE DERIVATIVES Russian patent published in 2017 - IPC C07D471/20 C07D487/10 C07D487/20 C07D519/00 A61K31/407 A61K31/437 A61K31/4439 A61K31/506 A61K31/5377 A61P35/00

Abstract RU 2612534 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a dispiropyrrolidine derivative of general formula (1), where ring A is a spiro compound 4-6-member saturated hydrocarbon ring, which can contain one or more substitutes, ring B is a benzene ring which can contain one or more substitutes, or a pyridine ring, which can contain one or more substitutes, R¹ is an aryl group which can contain one or more substitutes, or heteroaryl group, which can contain one or more substitutes, R² is a hydrogen atom; and R³ is a group presented by general formulae (2), (3) or (4), which inhibits protein interaction between Mdm2 and p53 protein and has antitumour activity.

EFFECT: dispiropyrrolidine derivatives are disclosed.

29 cl, 199 ex

R³:

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RU 2 612 534 C2

Authors

Dates

2017-03-09—Published

2012-03-09—Filed