FIELD: medicine.
SUBSTANCE: invention relates to compounds which are inhibitors of MKK4 (mitogen-activated protein kinase 4), pharmaceutical compositions based thereon and use for enhancing liver regeneration and reducing or preventing hepatocyte death.
EFFECT: obtaining compounds which selectively inhibit protein kinase MKK4 relative to protein kinases JNK and MKK7 and can be used to enhance liver regeneration and reducing or preventing death of hepatocytes associated with selective inhibition of protein kinase MKK4 relative to protein kinase JNK and MKK7.
6 cl, 8 tbl, 243 ex
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