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(19)

(11)

2 671 571

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P13/12(2006-01-01)

A61P15/16(2006-01-01)

A61P25/28(2006-01-01)

A61P31/18(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018107716, 2012-12-11

(24)

Start date

2012-12-11

(22)

Actual filing date

2012-12-11

(45)

Published

2018-11-02

(72)

Inventor

Wang, LePratt, John K.Mcdaniel, Keith F.Dai, YujiaFidanze, Steven D.Hasvold, LisaHolms, James H.Kati, Warren M.Liu, DachunMantei, Robert A.Mcclellan, William J.Sheppard, George S.Wada, Carol K.

(73)

Holder

Abbvie Inc.

BROMDOMAIN INHIBITORS Russian patent published in 2018 - IPC C07D471/04 A61K31/437 A61P13/12 A61P15/16 A61P25/28 A61P31/18 A61P35/00

Abstract RU 2671571 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to compound N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide or its pharmaceutically acceptable salt. Pharmaceutical composition comprising said compound, cancer treatment methods, acute renal disease or condition, acquired immunodeficiency syndrome (AIDS) and a method of contraception in a male subject.

EFFECT: technical result: compound with inhibitory BET bromdomain activity was obtained.

8 cl, 354 ex, 8 tbl

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RU 2 671 571 C1

Authors

Wang, Le

Pratt, John K.

Mcdaniel, Keith F.

Dai, Yujia

Fidanze, Steven D.

Hasvold, Lisa

Holms, James H.

Kati, Warren M.

Liu, Dachun

Mantei, Robert A.

Mcclellan, William J.

Sheppard, George S.

Wada, Carol K.

Dates

2018-11-02—Published

2012-12-11—Filed