FIELD: biotechnologies.
SUBSTANCE: methods are described to prevent a virus flu infection and detection of efficiency of a flu virus vaccine using a molecule of hemagglutinin (HA) of a flu virus A of subtype H5, immunogenicity of which is increased by replacement of amino acids in the HA sequence.
EFFECT: replacement of specific remains in HA, such as introduction of asparagin into the position 223 in HA H5, makes it possible to increase sensitivity of hemagglutination moderation reaction as a result of variation of receptor specificity or ability to binding of antibody-antigen.
24 cl, 7 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MODIFIED INFLUENZA VIRUS VACCINES | 2013 |
|
RU2552213C2 |
| MODIFIED INFLUENZA VIRUS FOR MONITORING AND INCREASING VACCINE EFFICACY | 2006 |
|
RU2420535C2 |
| STRAIN OF BIRD FLU VIRUS OF A/common gull/Chany/2006 H5N1 SUBTYPE FOR PREPARATION OF ANTIGEN-CONTAINING DIAGNOSTIC OR VACCINE MEDICATION | 2009 |
|
RU2400536C1 |
| IMMUNOGENIC EPITOPE OF INFLUENZA VIRUS | 2009 |
|
RU2546872C2 |
| RECOMBINANT VIRUS-LIKE PARTICLES (VLP) USING BOVINE IMMUNODEFICIENCY VIRUS GROUP-SPECIFIC ANTIGEN (GAG) PROTEIN | 2016 |
|
RU2734118C2 |
| STRAIN OF INFLUENZA VIRUS GKV 2389 FOR PRODUCTION OF LIVING INTRANASAL AND INACTIVATED INFLUENZA VACCINE | 2006 |
|
RU2318871C1 |
| NEW PROTEINS H5, MOLECULES OF NUCLEIC ACIDS THAT CODE THEM AND VECTORS, AND THEIR APPLICATION IN MEDICINE | 2007 |
|
RU2479589C2 |
| INFLUENZA VACCINE | 2011 |
|
RU2583297C2 |
| FUNCTIONAL INFLUENZA VIRUS-LIKE PARTICLES (VLPs) | 2006 |
|
RU2483751C2 |
| RECOMBINANT VIRUS-LIKE PARTICLES (VLP) USING A PROTEIN OF THE BOVINE IMMUNODEFICIENCY VIRUS GROUP ANTIGEN (GAG) | 2016 |
|
RU2757723C2 |
