FIELD: biotechnologies.
SUBSTANCE: methods are described to prevent a virus flu infection and detection of efficiency of a flu virus vaccine using a molecule of hemagglutinin (HA) of a flu virus A of subtype H5, immunogenicity of which is increased by replacement of amino acids in the HA sequence.
EFFECT: replacement of specific remains in HA, such as introduction of asparagin into the position 223 in HA H5, makes it possible to increase sensitivity of hemagglutination moderation reaction as a result of variation of receptor specificity or ability to binding of antibody-antigen.
24 cl, 7 tbl, 7 ex
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