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2 827 202

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IPC

C12N15/85(2006-01-01)

C07K14/00(2006-01-01)

(21) (22)

Application

2024107489, 2024-03-19

(24)

Start date

2024-03-19

(22)

Actual filing date

2024-03-19

(45)

Published

2024-09-23

(72)

Inventor

Rudometova Nadezhda BorisovnaFando Anastasiya AlekseevnaRudometov Andrej PavlovichBorgoyakova Mariya BorisovnaKisakov Denis NikolaevichKisakova Lyubov AleksandrovnaGudymo Andrej SergeevichIvanova Kseniya IvanovnaMarchenko Vasilij YurevichIlicheva Tatyana NikolaevnaIlichev Aleksandr AlekseevichKarpenko Larisa Ivanovna

(73)

Holder

Federalnoe Byudzhetnoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Federalnoj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchiya Cheloveka Gnts Vb Rospotrebnadzora)

RECOMBINANT PLASMID DNA pVL3-HA/H5 CARRYING INFLUENZA A (H5N8) VIRUS HEMAGGLUTININ GENE, A RECOMBINANT STRAIN OF CHINESE HAMSTER OVARY CELL LINE CHO-K1-H5 AND RECOMBINANT HEMAGGLUTININ OF INFLUENZA A (H5N8) VIRUS, PRODUCED BY CHO-K1-H5 STRAIN AND INTENDED FOR CREATION OF PREVENTIVE PREPARATIONS AND SEROLOGICAL DIAGNOSIS OF INFLUENZA A H5N8 VIRUS Russian patent published in 2024 - IPC C12N15/85 C07K14/00

Abstract RU 2827202 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to creation of a strain of recombinant cell line CHO-K1-H5 producing recombinant hemagglutinin of influenza A (H5N8) virus, which induces a specific immune response against highly pathogenic influenza A (H5N8) virus. RHA/H5 gene has been designed, plasmid DNA pVL3-HA/H5 having the nucleotide sequence SEQ ID NO: 1 5989 bp, molecular weight 3,700,705 Da, containing the target gene coding protein-immunogen HA/H5 SEQ ID NO: 2. Strain of the recombinant cell line CHO-K1-H5 and recombinant hemagglutinin of the influenza A (H5N8) virus, produced by the above cell line strain CHO-K1-H5 and inducing a specific immune response against the highly pathogenic influenza A (H5N8) virus.

EFFECT: recombinant cell line CHO-K1-H5 producing recombinant protein hemagglutinin of influenza A (H5N8) virus, which is capable of inducing a specific protective humoral immune response against influenza A (H5N8) virus.

3 cl, 8 dwg

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RU 2 827 202 C1

Authors

Rudometova Nadezhda Borisovna

Fando Anastasiya Alekseevna

Rudometov Andrej Pavlovich

Borgoyakova Mariya Borisovna

Kisakov Denis Nikolaevich

Kisakova Lyubov Aleksandrovna

Gudymo Andrej Sergeevich

Ivanova Kseniya Ivanovna

Marchenko Vasilij Yurevich

Ilicheva Tatyana Nikolaevna

Ilichev Aleksandr Alekseevich

Karpenko Larisa Ivanovna

Dates

2024-09-23—Published

2024-03-19—Filed