FIELD: medicine.
SUBSTANCE: invention refers to biotechnology and virology. What is presented is a method for preparing an immunogenic composition. The method provides preparing a recombinant haemagglutinin (HA) molecule of influenza A virus subtype H5 (HA H5) and mixing the recombinant molecule with a pharmaceutically acceptable carrier and/or excipient. The recombinant molecule contains an asparagine substitute in position 223 of amino acid sequence as compared to the respective wild-type molecule. Substitution of specific residues in HA, such as asparagine introduction in position 223 in HA H5 enables increasing haemagglutination inhibition reaction sensitivity as a result of receptor specificity and/or ability to binding of antibody-antigen.
EFFECT: invention can be used in medicine.
14 cl, 3 dwg, 7 tbl, 7 ex
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