METHOD FOR EARLY PREDICTION OF CLINICAL OUTCOME OF ANTIVIRAL THERAPY FOR CHRONIC VIRAL HEPATITIS C Russian patent published in 2013 - IPC C12Q1/70 

FIELD: medicine.

SUBSTANCE: what is presented is a method for early prediction of the clinical outcome of an antiviral therapy for chronic viral hepatitis C involving detecting the immunological parameters in patient's venous blood, including the content of circulating immune complexes (CIC), and the virological parameters (hepatitis C genotype). Before the beginning of the antiviral therapy, the complex is analysed for B-lymphocytes (CD₁₉), T-suppressor cells (CD₈), natural killer cells (CD₁₆), the level of immunoglobulin A (IgA), and the percentage of phagocytosis (F%). Total weight coefficients of the parameters is used to derive an immunological prediction coefficient (IPC). If the IPC value is 1.2 ÷ 3.2, the favourable outcome is predicted, the IPC values being 3.3 ÷ 3.9 shows potential recurrence, while if the IPC value exceeds 3.9, the unfavourable outcome is stated.

EFFECT: effective method for prediction of the clinical outcome of the antiviral therapy before the beginning thereof preventing the need for expensive treatment and inefficient expenditure of monetary resources.

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