FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine. A dosage form for treating mycotic infections contains nanosomes of cholesterol-containing amphotericin B of the diameter within the range of 20-200 nm in physiologic saline, the ratio of lipid to amphotericin B ranges from 45:1 to 45:15. Amphotericin B is exposed to ultrasound to destruct at the final stage to transform the particles into smaller and less lamellar nanosomes.
EFFECT: invention provides lower nephrotoxicity and effective antimycotic activity.
3 cl, 11 tbl, 3 dwg, 7 ex
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