FIELD: medicine.
SUBSTANCE: invention covers a composition applied in therapy of infections caused by fungi Aspergillus in human and animals. The composition contains an antibody or its antigen binding fragment specific at least to one epitope hsp90 from an organism Aspergillus, and at least one antimycotic means chosen from the group containing itraconazole, posaconazole and voriconazole. Epitope is presented by peptides with certain amino acid sequences presented in the description. There is a combined preparation based on the composition and intended for simultaneous, separate or consecutive application in treating said infection. The invention shows possibility to use the composition in implementing the method for preparing a drug of said appointment. There is also described therapy of aspergillosis with using the composition and also a set comprising the drug described above, used in treating the infections caused by fungi Aspergillus.
EFFECT: invention allows administering lower doses of drugs without reducing clinical effectiveness, and improving clinical effectiveness in standard doses with reducing herewith undesired by-effects.
29 cl, 4 tbl
Authors
Dates
2010-01-27—Published
2005-04-18—Filed