FIELD: chemistry.
SUBSTANCE: invention relates to a novel N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(5-isopropoxy-1H-pyarazol-3-yl)-3H-imidazo[4,5-b]pyridine-5-amine or pharmaceutically acceptable salt thereof, having inhibiting activity with respect to Trk (tropomyosin-related kinase). The compounds can be used as a medicinal agent for treating cancer. The invention also relates to use of said compound of pharmaceutically acceptable salt thereof to produce a medicinal agent for treating cancer in a warm-blooded animal and a pharmaceutical composition containing said compound or pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier, a solvent or an inert filler.
EFFECT: high efficiency of using the compound.
4 cl, 26 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRAZOLYLAMINOPYRIDINE DERIVATIVES APPLICABLE AS KINASE INHIBITORS | 2006 |
|
RU2415852C2 |
| SELECTIVE KINASE JAK1 INHIBITOR | 2020 |
|
RU2818002C2 |
| MACROCYCLIC TYROSINE KINASE INHIBITOR AND ITS USE | 2019 |
|
RU2798231C2 |
| MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | 2019 |
|
RU2778294C2 |
| HETEROCYCLIC ANALOGUES OF PYRIMIDINES AS JAK INHIBITORS | 2012 |
|
RU2564419C1 |
| AMINOPYRAZOLOPYRIMIDINE COMPOUND USED AS INHIBITOR OF TYROSINE KINASE RECEPTOR OF NEUROTROPHIC FACTOR | 2017 |
|
RU2764523C2 |
| METHOD FOR PREPARING DIHYDROINDENAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USING THEM AS PROTEIN KINASE INHIBITOR | 2009 |
|
RU2528408C2 |
| NEW INHIBITOR BASED ON A QUINOLINE DERIVATIVE | 2019 |
|
RU2802283C2 |
| SERINE/THREONINE KINASE INHIBITORS | 2013 |
|
RU2650501C2 |
| HETEROCYCLIC COMPOUNDS AS TRK INHIBITORS | 2019 |
|
RU2803817C2 |
