MACROCYCLIC TYROSINE KINASE INHIBITOR AND ITS USE Russian patent published in 2023 - IPC C07D471/22 C07D498/22 A61K31/4375 A61K31/439 A61K31/519 A61P25/28 A61P29/00 A61P35/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: group of inventions includes a compound of formula (I), or a pharmaceutically acceptable salt thereof, a stereoisomer, a pharmaceutical composition and the use of a compound of formula (I) for the preparation of a medicinal product. In formula (I), M¹, M², M⁴, M⁵ and M⁶ are each independently selected from C(R¹) and N; M³ and M⁷ are C; X¹, X², X³ and L¹, if present, are each independently selected from -C(R⁵)(R⁶)-, -N(R⁴)- and -O; ring A is selected from phenyl, pyridinyl, pyrimidinyl and pyridazinyl; cycle B is absent, X² and X³ are directly connected by a chemical bond; R¹, R², R³, R⁵ and R⁶, if present, are each independently selected from hydrogen, halogen and the following groups, optionally substituted with one to three Q¹: C_1-6alkyl, -OR^a; Q¹, if present, is halogen; R⁴, if present, is independently selected from hydrogen and C_1-6 alkyl; or X¹ together with L¹ forms pyrrolidinyl; R^a, when present, is selected from C_1-6 alkyl, haloC_1-6 alkyl; m, n, p, q, and t are each independently selected from either 0, 1, 2, 3, 4, or 5.

EFFECT: compound of formula (I) with inhibitory activity against TRK and/or ROS1 tyrosine kinases.

19 cl, 10 tbl, 7 ex