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2 778 294

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(51)

IPC

C07D487/22(2006-01-01)

C07D498/22(2006-01-01)

A61K31/519(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2020133631, 2019-03-27

(24)

Start date

2019-03-27

(22)

Actual filing date

2019-03-27

(45)

Published

2022-08-17

(72)

Inventor

Chzhan, KhuatszeLyu, TsikhunKhe, ChensiChzhan, VejpenTan, ZhujLyu, BinFu, KhunTan, KhaokhanYan, LitszyunLyu, KhunbinVan, YunlinGao, YujvejTszou, TszunyaoLyu, YansinLin, ShuLi, TunshuanChzhao, SindunVan, Vejbo

(73)

Holder

Fochon Bajosajensis, Ltd.

MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS Russian patent published in 2022 - IPC C07D487/22 C07D498/22 A61K31/519 A61P35/00

Abstract RU 2778294 C2

FIELD: medicine.

SUBSTANCE: invention relates to compounds of the formula I, where X, Y, L, Z¹-Z⁷, R¹-R⁵, m, n, and p are defined in the claims.

EFFECT: compounds can inhibit protein tyrosine kinases of TRK family, and they can be used for the treatment of hyperproliferative diseases.

29 cl, 2 tbl, 100 ex

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RU 2 778 294 C2

Authors

Chzhan, Khuatsze

Lyu, Tsikhun

Khe, Chensi

Chzhan, Vejpen

Tan, Zhuj

Lyu, Bin

Fu, Khun

Tan, Khaokhan

Yan, Litszyun

Lyu, Khunbin

Van, Yunlin

Gao, Yujvej

Tszou, Tszunyao

Lyu, Yansin

Lin, Shu

Li, Tunshuan

Chzhao, Sindun

Van, Vejbo

Dates

2022-08-17—Published

2019-03-27—Filed