METHOD FOR ASSESSING DEGREE OF DEGENERATION IN NERVE TISSUE REGENERATION PATIENTS WITH COMPLICATED CERVICAL SPINE INJURY Russian patent published in 2013 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: every 7^th postoperative day, TNF_α, interleukines IL1, IL4, IL6, IL10, matrix metalloproteinases MMP-2 and MMP-9, anti-neuronal immunoglobulin anti-MAG, phosphorylated neurofilament pNF-H, myelin basic protein MBP, tissue inhibitor of metalloproteinase TIMP-1 are evaluated. A nerve tissue injury factor $$K_i=-\frac{MMP-2+MMP-9}{TIMP-1}\cdot \sqrt{pNF-H},$$ , a nerve tissue regeneration factor $$K_r=+\frac{MBP}{anti-MAG}$$ and a mixed antagonist reaction adjustment factor $$K_{MARS}=\frac{IL1+IL6}{IL4+IL10}\cdot \sqrt{TN{F}_{\alpha }}$$ are calculated. The derived factors are evaluated, and their total value ∑K_i+K_r-K_MARS is used to describe a degree of degeneration in the nerve tissue remodelling process: the values of -0.1 to -50.0 show a mild process of the nerve tissue degeneration, the values of -50.1 to -100.0 show a moderate process of the nerve tissue degeneration, and the values of -100.1 and less show the manifested nerve tissue degeneration.

EFFECT: invention provides the more objective assessment of the degree of degeneration accompanying the nerve tissue remodelling process in the patients with a complicated cervical spine injury that enables correcting a therapeutic approach.

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