METHOD FOR PREPARING STABILISER-COATED NANOCRYSTALLINE CERIUM DIOXIDE Russian patent published in 2013 - IPC A61K33/24 A61K47/36 A61P39/06 A61J3/00 B82B3/00 B82Y5/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for preparing stabiliser-coated nanocrystalline cerium dioxide characterised by antioxidant activity. The method involves preparing an aqueous solution of cerium salt and a stabiliser representing maltodextrin with a molar ratio of cerium to the stabiliser 1 to 1-4. Then, the prepared aqueous solution is added with drops of hydrous ammonia with stirring, and pH of the prepared solution is gradually increased to 7-8, maintained for 1-4 hours, the prepared colloidal solution of hydrous cerium nanoparticles is added with hydrous ammonia, and pH is increased to 11-12 and maintained for 1-10 hours to form a colloidal solution of cerium dioxide. Thereafter, an alcohol or ketone excess is removed and brought to the boiling point, while the formed precipitate of the non-aggregated nanoparticles of stabiliser-coated cerium dioxide, separated by decantation or filtration, washed 1-4 times in alcohol or ketone, and dried at temperature 50-80°C to constant weight. The prepared powder of the non-aggregated nanoparticles of stabiliser-coated cerium dioxide is re-dispersed in a polar solvent to form aggregation resistant sol.

EFFECT: invention provides preparing stabilised nanocrystalline cerium dioxide with a hydrodynamic diameter of 6-10 nm.

3 cl, 7 dwg, 4 ex