DIAGNOSTIC TECHNIQUE FOR PATHOLOGIES RELATED TO ENDOCRINOPATHIES Russian patent published in 2013 - IPC G01N33/50 G01N30/02 

FIELD: medicine.

SUBSTANCE: method consists in determining a characteristic profile of a test sample of a human biological fluid. It is concentrated off-line. Biologically active substances are separated using complexing additives, and a 'reference' is determined. Steroid hormones are taken as the analysed biologically active substances. The hormones are separated by performed by reversed-phase HELC in gradient elution using a diode array detector. The steroid profiles are used to form a matrix of the analytical signal intensities and the retention factors of each steroid. Each sample is graphically imaged by method of principal components, and the graphical images are used to form 'reference' and deviation clusters. The 'reference' and deviation clusters are corrected by soft independent modelling of class analogy taken as a reference. The pathologies are diagnosed by an ability of the patient's image to come with a 'reference' or a deviation.

EFFECT: reliable diagnosis of the pathologies associated with adrenal cortical diseases.

6 dwg, 2 ex