HYPOALLERGIC FUSED PROTEIN, NUCLEIC ACID MOLECULE CODING IT, EXPRESSION VECTOR, HOST CELL, VACCINE COMPOSITION, AND USE THEREOF Russian patent published in 2013 - IPC C07K19/00 C12N15/62 C12N15/63 C12N5/10 A61K38/16 A61K39/35 

FIELD: medicine, pharmaceutics.

SUBSTANCE: inventions refers to biotechnology and concern hypoallergic fused proteins. A presented hypoallergic fused protein consists of one hypoallergic molecule originated from an allergen, fused with a second non-allergic protein originated from a pathogen, or a fragment thereof with the hypoallergic molecule originated from the allergen showing 50% decreased ability to bind IgE, 30% decreased T-cell responsiveness as compared with a wild-type allergen. A nucleic acid molecule coding the fused protein, an expression vector, a host cell expressing the same protein, and a vaccine composition containing the protein are also presented.

EFFECT: presented invention enables preparing therapeutic and prophylactic drugs for an allergy or diseases caused by pathogens with using no toxic adjuvants, showing no side effects.

14 cl, 23 dwg, 17 tbl, 27 ex