METHOD OF OBTAINING BIS[3-METHYL(ADAMANT-1-YL)]UREA Russian patent published in 2013 - IPC A61K31/00 C07C275/28 C07C275/18 

Abstract RU 2486893 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to method of obtaining novel bis[3-methyl(adamant-1-yl)]urea of general formula: , where . Obtained products can be applied in chemical-pharmaceutical industry. Method consists in interaction of 1-aminomethyladamantane with diisocyanates selected from line hexamethylene-1, 6 or 4,4'-diphenylmethane diisocyanate, at temperature 15-25 °C, for 2-4 hours in dimethylformamide with molar ratio diisocyanate: amine: dimethylformamide (1:2.04-2.12:87-129) and separation of target product.

EFFECT: compounds are obtained with 93-94% product output.

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RU 2 486 893 C1

Authors

Butov Gennadij Mikhajlovich

Burmistrov Vladimir Vladimirovich

Dates

2013-07-10Published

2012-06-13Filed