STEROID LIGANDS AND USE THEREOF IN GENE SWITCH MODULATION Russian patent published in 2013 - IPC C07J1/00 A01N45/00 A61K31/56

Abstract RU 2487134 C2

FIELD: chemistry.

SUBSTANCE: invention relates to steroid ligands for use in nuclear receptor-based inducible gene expression systems. The invention also relates to methods of modulating the expression of genes of interest using a system containing one or more nuclear receptor complexes and one or more steroid ligands. Other aspects include ligand compositions including therapeutic compositions.

EFFECT: improved method.

21 cl, 1 ex, 9 tbl, 20 dwg

Similar patents RU2487134C2

Title	Year	Author	Number
CHIRAL DIACYLHYDRAZINE LIGANDS FOR MODULATION OF EXOGENOUS GENES EXPRESSION BY ECDYSONE-RECEPTOR COMPLEX	2013	Hormann Robert E. Li Bing	RU2640807C2
BORON-CONTAINING DIACYLHYDRASINES	2014	Chellappan Shila K. Khorman Robert E. Shulman Inna	RU2637946C2
CHIRAL DIACYL-HYDRAZINE LIGANDS FOR MODULATING EXPRESSION OF EXOGENIC GENES BY MEANS OF ECDYSONE-RECEPTOR COMPLEX	2008	Khormann Robert I. Li Bing	RU2490253C2
MUTANT RECEPTORS AND THEIR APPLICATION IN INDUCIBLE GENE EXPRESSION SYSTEM BASED ON NUCLEAR RECEPTOR	2005	Palli Sabba Reddi Kumar Mokhan Basavaraji	RU2539036C2
COMBINATION OF INHIBITORS OF FBP-ASE AND SENSITIZING AGENTS OF INSULIN FOR DIABETES MELLITUS TREATMENT	1999	Ehrion Mark D. Van Pul'E Paul'	RU2227749C2
COMPOUNDS EXHIBITING SELECTIVITY WITH RESPECT TO RETINOID RECEPTORS, PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD OF MODULATION OF PROCESSES (VARIANTS), METHOD OF SUPPRESSION OF PATHOLOGICAL STATES	1993	Markus F.Boehm Richard A.Khejman Lin Tskhi	RU2144913C1
EMPHYSEMA TREATMENT USING RETINOID AGONIST (RAR) ELICITING SELECTIVE EFFECT	2000	Belloni Pola Nanett Klaus Mikhaehl'	RU2257383C2
CONSTRUCTED CELLS, EXPRESSING MULTIPLE IMMUNOMODULATORS, AND THEREOF APPLICATION	2009	Bich Robert Patterson Rid Tomas D.	RU2573912C2
PHARMACEUTICAL APPLICATION OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUND	2014	Lyu Khun Se Sin Sun Khajfen Li Tszin Chzhao Fej Chen In Li Tszen Chzhou Yuj Tszyan Khualyan Chen Kajsyan	RU2704257C2
MODIFIED DENDRITIC CELLS AND THEIR APPLICATION FOR MALIGNANT TUMOURS TREATMENT	2013	Brauler Dzh. Mark Kumar Prasanna Storkus Uolter Dzh. Okada Khidekho	RU2644210C2

RU 2 487 134 C2

Authors

Khormann Robert I.

Lapenna Sil'Vija

Dates

2013-07-10—Published

2009-03-16—Filed