FIELD: medicine, endocrinology, biochemistry, pharmacy. SUBSTANCE: invention proposes a pharmaceutical composition based on thiazolidinedione sensitizing agent of insulin and inhibitor of FBA-ase, method for treatment of diabetes mellitus and method for treatment of resistance to insulin or hyperglycemia using above indicated composition. Invention provides the effectiveness of treatment due to the synergetic effect of the composition components and to reduce adverse effects in mammals. EFFECT: valuable medicinal properties of composition. 141 cl, 4 tbl
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