FIELD: chemistry.
SUBSTANCE: claimed invention relates to field of biotechnology and can be used for recombinant expression of immunomodulatory proteins. Vector, containing polynucleotide which codes gene switch, is constructed, with said polynucleotide containing (1) at least one transcription factor sequence which is functionally bound with promoter, with said at least one transcription factor sequence coding ligand-dependent transcription factor, and (2) polynucleotide, which codes peptide IL-12 an one or more immunomodulatory polypeptides, selected from IL-2, IL-7, IL-15, IL-18, IL-21, GM-CSF, CCL3 (MIP-1a), CCL5 (RANTES), CCL7 (MCP3), XCL1 (lymphotactin), CCL19 (MIP-3b), CXCL9 (MIG), CXCL10 (IP-10), CXCL12 (SDF-1), CCL21 (6Ckine) or TNF-alpha.
EFFECT: invention makes it possible to use vector for controlled expression of immunomodulatory proteins.
12 cl, 9 dwg, 4 tbl, 2 ex
