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2 487 358

(13)

(51)

IPC

G01N33/50(2006-01-01)

(21) (22)

Application

2010105971/15, 2008-09-05

(24)

Start date

2008-09-05

(22)

Actual filing date

2008-09-05

(45)

Published

2013-07-10

(72)

Inventor

Shreder Mari A.Koklin Louri I.Aterton Khelen Dzh.Khiter Lajza K.Klark KiranRadda Dzhordzh K.Tajler Damian Dzh.

(73)

Holder

Dzhi-I Kheltker Limited

METHOD OF DETERMINATION OF PYRUVATE DEHYDROGENASE (PDH) ACTIVITY AND MEDIUM OF VISUALISATION FOR IMPLEMENTATION IN SAID METHOD Russian patent published in 2013 - IPC G01N33/50

Abstract RU 2487358 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to determining the activity of pyruvate dehydrogenase complex (PDH complex) by ¹³C-MP detection (magnetic resonance detection based on the isotope ¹³C). The essence of the method consists in that the change in activity of PDH complex in the subject to be examined by ¹³C-MR detection (magnetic resonance detection based on the isotope ¹³C) is determined using the medium of visualisation comprising hyperpolarised ¹³C-pyruvate, and when detecting a signal of ¹³C-bicarbonate or the signal of ¹³C-bicarbonate and the signal of ¹³C-pyruvate where the said hyperpolarised ¹³C-pyruvate is selected from the group consisting of hyperpolarized ¹³C₁-pyruvate, ¹³C_1,2-pyruvate, ¹³C_1,3-pyruvate or ¹³C_1,2,3-pyruvate or any of their combination, the activity of PDH complex is determined.

EFFECT: use of the claimed method enables to determine reliably changes in activity of PDH complex in the subject to be examined.

11 cl, 7 dwg, 5 ex

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RU 2 487 358 C2

Authors

Shreder Mari A.

Koklin Louri I.

Aterton Khelen Dzh.

Khiter Lajza K.

Klark Kiran

Radda Dzhordzh K.

Tajler Damian Dzh.

Dates

2013-07-10—Published

2008-09-05—Filed