VISUALISATION TECHNIQUE TO DISTINGUISH HEALTHY TISSUE FROM TUMOR TISSUE Russian patent published in 2009 - IPC A61K49/06 A61B5/55 G01N33/483 

Abstract RU 2369406 C2

FIELD: medicine.

SUBSTANCE: invention can be used for tumor visualisation using hyperpolarisable 13C-pyruvate as magnetic resonance imaging agent, which can distinguish healthy tissue from tumor tissue. The following shall be performed: a) acquisition of direct 13C-MP images of 13C-pyruvate and its 13C-containing metabolites of alanine and lactate in the patient previously injected with composition containing hyperpolarisable 13C-pyruvate, b) correcting lactate signal with respect to quantity of pyruvate and/or alanine with acquisition of lactate relative to pyruvate and/or lactate relative to alanine image whereby tumor tissue is indicated by the highest signal and/or high weighted lactate signal relative to pyruvate signal and/or lactate signal relative to alanine signal in specified13C-images.

EFFECT: improved imaging accuracy when distinguishing healthy tissue from tumor tissue.

8 cl, 2 dwg, 5 ex

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RU 2 369 406 C2

Authors

Taning Mikkel'

Zandt Rene In`T

Dates

2009-10-10Published

2005-07-28Filed