COMPOUNDS HAVING ARYLSULPHONAMIDE STRUCTURE, USED AS METALLOPROTEASE INHIBITORS Russian patent published in 2013 - IPC C07C311/48 C07D295/08 C07D209/48 A61K31/18 A61K31/4035 A61K31/495 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to arylsulphonamide compounds, having the formula given below , where R is a group of formula -Ar-X-Ar' (II), where Ar is a phenylene group and Ar' is a phenyl group; wherein said phenylene group and phenyl group are optionally substituted with one group selected from a straight or branched C_1-4alkoxy group; X is a single bond or -O-; R₁ is a -ORa group, where Ra is selected from straight or branched C₁-C₄alkyl groups; or Ra is a group of formula -(CH₂)_p-Z-(CH₂)_r-W (III), where in formula (III) p equals 1 or 2; Z is a single bond or a bivalent linker selected from -O-; r equals 0, 1 or 2, and W is phenyl or piperazine, each of which is optionally substituted with one or more groups selected from -COR', where R' is a straight or branched C_1-4alkyl; R₂ and R₃ are identical or different and each is independently H or a zinc-binding group, selected from a group consisting of -COOH, and -CONHOH; R₄ is a group selected from -CORc, -COORc and -S(O)₂Rc, where Rc is a group selected from a straight or branched alkyl, phenyl, phenylakyl, having 1 to 4 carbon atoms in the alkyl chain; R₅ is H or R₄ and R₅ together with a N atom to which they are bonded form a N-phthaloimido group , n equals 2; m equals an integer from 1 to 6; or pharmaceutically acceptable salts thereof. The invention also relates to a method of producing arylsulphonamide compounds, pharmaceutical compositions containing said compounds and use thereof as therapeutic agents, for treating degenerative disorders involving metalloprotease MMP-2, MMP-13, MMP-14.

EFFECT: arylsulphonamide compounds having metalloprotease MMP-2, MMP-13, MMP-14 inhibiting activity.

15 cl, 1 tbl, 17 ex