HETEROCYCLIC COMPOUND Russian patent published in 2013 - IPC C07D207/08 C07D207/12 C07D207/26 C07D207/27 C07D207/273 C07D275/02 C07D307/16 A61K31/4015 A61K31/402 A61K31/425 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to heterocyclic compounds of formula:

or a pharmaceutically acceptable salt thereof, wherein: the ring A means a 5-member nonaromatic heterocycle specified in N, O, with one heteroatom optionally additionally substituted by one substitute =O; the ring B means a benzene ring optionally additionally substituted by 1-3 substitutes specified in: C_1-6alkoxy optionally substituted by 1-3 halogens, halogen, C_1-6alkyl optionally substituted by 1-3 halogens, X means a bond, O, CH₂O, OCH₂, CH₂, (CH₂)₂, S, CH₂S, SCH₂, S(O), CH₂S(O), S(O)CH₂, S(O)₂, CH₂S(O)₂ or S(O)₂CH₂, provided {2-oxo-1-[3-(trifluoromethyl)phenyl]-pyrrolidin-3-yl}acetic acid, and {5-oxo-1-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-yl}acetic acid are eliminated.

EFFECT: compounds are used to prepare a therapeutic agent decreasing retinol-binding protein 4 that enables using them for treating diabetes.

14 cl, 22 dwg, 4 tbl, 78 ex