SUBSTITUTED MORPHOLINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF DECREASE OF TACHIKININ LEVEL IN TREATMENT OR PROPHYLAXIS OF PHYSIOLOGICAL STATES ASSOCIATED WITH TACHIKININ EXCESS Russian patent published in 1999 - IPC

FIELD: organic chemistry, physiology. SUBSTANCE: invention relates to the substituted derivatives of morpholine of the formula (I) where R¹,R² - hydrogen, halogen atom, alkyl, alkoxy-group or CF₃; R³ - hydrogen, halogen atom or CF₃; R⁴ - hydrogen atom; R⁵ - hydrogen atom or 4-fluoro-group; R⁶ - 5- or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms possibly substituted with =O, =S, alkyl or ZNR⁷; Z is C_1-4-alkylene; R⁷ - hydrogen atom, alkyl, C_3-7-cycloalkyl or C_3-7-cycloalkyl-C_1-4-alkyl or C_2-4-alkyl substituted with alkoxy- or hydroxyl-group, or its pharmaceutically acceptable salts and a pharmaceutical composition based on their base which shows property of tachikinin antagonists. EFFECT: improved method of synthesis, decrease of tachikinin level. 28 cl, 4 tbl, 106 ex