MACROCYCLIC PHENYLCARBAMATES INHIBITING HCV Russian patent published in 2013 - IPC C07D245/04 C07D255/04 C07D401/12 C07D417/12 C07D498/04 A61K31/538 A61P31/14 

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are described macrocyclic phenylcarbamates of formula (I), wherein A represents -C(=O)OR¹ or -C(=O)-NH-SO₂-R², wherein R¹ represents hydrogen or C₁-C₆alkyl; R² represetns C₃-₇cycloalkyl, phenyl, thiazolyl or pyridyl each of which is optionally substituted by one or more substituted specified in C_1-6alkyl, C_1-6alkoxy, trifluoromethyl and halogen; X represents N or CH; E represents NR⁵; R⁵ represents hydrogen, C_1-6alkyl, C_1-6alkoxyC_1-6alkyl or C_3-7cycloalkyl; n is equal to 4 or 5; wherein a dash line -----, adjoining the fragment -(CH₂)_n-, represents a double bond; and wherein the dash line in a five-merous cycle including X, represents a single bond, and R⁷ represents hydrogen; R⁸ is such as specified in the patent claim, or N-oxide thereof, a pharmaceutically acceptable additive salt or a pharmaceutically acceptable solvate possessing antiviral activity, and used as HCV inhibitors; as well as pharmaceutical compositions containing the above compounds as an active ingredient.

EFFECT: preparing the pharmaceutically acceptable additive salt or pharmaceutically acceptable solvate possessing antiviral activity.

10 cl, 23 ex, 1 tbl