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2 518 471

(13)

(51)

IPC

C07D515/08(2006-01-01)

A61K31/407(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2011109196/04, 2009-08-14

(24)

Start date

2009-08-14

(22)

Actual filing date

2009-08-14

(45)

Published

2014-06-10

(72)

Inventor

Mak Gouen Dehvid KrejgVendevill' Sandrin Mari EhlenRabuasson P'Er Zhan-Mari BernarTakhri Abdellakh

(73)

Holder

Tibotek Farmas'Jutikalz

MACROCYCLIC INDOLE DERIVATIVES, APPLICABLE AS INHIBITORS OF HEPATITIS C VIRUS Russian patent published in 2014 - IPC C07D515/08 A61K31/407 A61P31/14

Abstract RU 2518471 C2

FIELD: chemistry.

SUBSTANCE: invention relates to formula compound, including its stereochemically isomeric forms, hydrates and solvates, where R₁ is selected from hydrogen atom, halogen atom and C_1-4-alkoxy; R₂ is selected from C_1-4-alkyl and C_3-6-cycloalkyl; R₄ represents C_3-7-cycloalkyl; n equals 1; Y is selected from and a equals 4 or 5; R₃ and R_3' are independently selected from hydrogen atom and C_1-6-alkyl. Invention also relates to antiviral pharmaceutical composition based on said formula (I) compound.

EFFECT: obtained are novel compounds and based on them pharmaceutical compositions, which can be applied in medicine in HCV therapy.

12 cl, 3 tbl, 15 ex

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RU 2 518 471 C2

Authors

Mak Gouen Dehvid Krejg

Vendevill' Sandrin Mari Ehlen

Rabuasson P'Er Zhan-Mari Bernar

Takhri Abdellakh

Dates

2014-06-10—Published

2009-08-14—Filed